Drug interactions
Chlorthalidone + Glipizide-metformin
Severity: Moderate
Chlorthalidone and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as chlorthalidone can raise blood glucose and impair glucose tolerance, reducing the effect of glipizide and metformin. The effect is dose-related and usually modest.
What this interaction means in plain words
Chlorthalidone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via reduced insulin secretion and sensitivity, partly mediated by potassium depletion.
What to do
Monitor blood glucose and serum potassium after starting chlorthalidone and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Glipizide-metformin?
MediHelp rates the interaction as moderate. Chlorthalidone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as chlorthalidone can raise blood glucose and impair glucose tolerance, reducing the effect of glipizide and metformin. The effect is dose-related and usually modest.
How serious is the interaction between Chlorthalidone and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting chlorthalidone and adjust antidiabetic therapy if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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