Drug interactions
Chlorthalidone + Hydrochlorothiazide-telmisartan
Severity: Moderate
Chlorthalidone and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone duplicates the thiazide component, increasing the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion with little added benefit.
What this interaction means in plain words
Chlorthalidone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the sodium-chloride cotransporter in the distal tubule leading to additive diuresis and electrolyte loss.
What to do
Avoid duplicate thiazide-type therapy where possible; if used intentionally, monitor electrolytes and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone duplicates the thiazide component, increasing the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion with little added benefit.
How serious is the interaction between Chlorthalidone and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy where possible; if used intentionally, monitor electrolytes and renal function closely.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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