Drug interactions
Chlorthalidone + Hydrochlorothiazide-valsartan
Severity: Moderate
Chlorthalidone and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining chlorthalidone with a product that already contains hydrochlorothiazide duplicates thiazide-type diuretic therapy. This increases the risk of excessive diuresis, hypokalemia, hyponatremia, hypotension and renal function decline, with little added benefit.
What this interaction means in plain words
Chlorthalidone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter by two thiazide-type diuretics, increasing urinary sodium and potassium loss.
What to do
Avoid routine therapeutic duplication and use only one thiazide-type agent unless a specialist deliberately combines them. If both are used, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining chlorthalidone with a product that already contains hydrochlorothiazide duplicates thiazide-type diuretic therapy. This increases the risk of excessive diuresis, hypokalemia, hyponatremia, hypotension and renal function decline, with little added benefit.
How serious is the interaction between Chlorthalidone and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine therapeutic duplication and use only one thiazide-type agent unless a specialist deliberately combines them. If both are used, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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