Drug interactions
Chlorthalidone + Meloxicam
Severity: Moderate
Chlorthalidone and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can reduce the diuretic and antihypertensive effects of chlorthalidone and may contribute to renal impairment, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Chlorthalidone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and decreased renal perfusion, opposing thiazide-type diuresis.
What to do
Monitor blood pressure, fluid status and renal function. Ensure adequate hydration and adjust antihypertensive therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Meloxicam?
MediHelp rates the interaction as moderate. Chlorthalidone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can reduce the diuretic and antihypertensive effects of chlorthalidone and may contribute to renal impairment, particularly in volume-depleted or elderly patients.
How serious is the interaction between Chlorthalidone and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function. Ensure adequate hydration and adjust antihypertensive therapy as needed.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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