Drug interactions
Chlorthalidone + Naproxen
Severity: Moderate
Chlorthalidone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can attenuate the diuretic and antihypertensive effects of chlorthalidone and may contribute to renal impairment in volume-depleted patients.
What this interaction means in plain words
Chlorthalidone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, edema and renal function and electrolytes during concurrent use. Use the lowest NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Naproxen?
MediHelp rates the interaction as moderate. Chlorthalidone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can attenuate the diuretic and antihypertensive effects of chlorthalidone and may contribute to renal impairment in volume-depleted patients.
How serious is the interaction between Chlorthalidone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function and electrolytes during concurrent use. Use the lowest NSAID dose for the shortest duration.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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