Drug interactions
Chlorthalidone + Propranolol
Severity: Minor
Chlorthalidone and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Used together, they give additive blood pressure reduction. Both can impair glucose control and propranolol may mask hypoglycemia symptoms. Chlorthalidone-related hypokalemia is not reliably countered by propranolol.
What this interaction means in plain words
Chlorthalidone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects and overlapping adverse effects on glucose and lipid metabolism.
What to do
Monitor blood pressure, heart rate, potassium and glucose, particularly in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Chlorthalidone with Propranolol?
MediHelp rates the interaction as minor. Chlorthalidone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Used together, they give additive blood pressure reduction. Both can impair glucose control and propranolol may mask hypoglycemia symptoms. Chlorthalidone-related hypokalemia is not reliably countered by propranolol.
How serious is the interaction between Chlorthalidone and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, potassium and glucose, particularly in diabetic patients.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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