Drug interactions
Chlorthalidone + Sacubitril-valsartan
Severity: Moderate
Chlorthalidone and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone causes potassium loss while the angiotensin receptor blocker reduces potassium excretion, so net effects vary. Combined use adds to blood pressure lowering and can cause volume depletion, hyponatremia and renal function decline.
What this interaction means in plain words
Chlorthalidone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium excretion and additive natriuretic and hypotensive effects.
What to do
Monitor serum potassium, sodium, creatinine and blood pressure after initiation and dose changes. Adjust the diuretic dose if volume depletion or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone causes potassium loss while the angiotensin receptor blocker reduces potassium excretion, so net effects vary. Combined use adds to blood pressure lowering and can cause volume depletion, hyponatremia and renal function decline.
How serious is the interaction between Chlorthalidone and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium, creatinine and blood pressure after initiation and dose changes. Adjust the diuretic dose if volume depletion or hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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