Drug interactions
Chlorthalidone + Tolmetin
Severity: Moderate
Chlorthalidone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-like diuretics and, in volume-depleted patients, increase the risk of acute kidney injury.
What this interaction means in plain words
Chlorthalidone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduces renal perfusion, opposing the diuretic effect.
What to do
Monitor blood pressure, renal function and electrolytes, and adjust antihypertensive therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Tolmetin?
MediHelp rates the interaction as moderate. Chlorthalidone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-like diuretics and, in volume-depleted patients, increase the risk of acute kidney injury.
How serious is the interaction between Chlorthalidone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and adjust antihypertensive therapy if control deteriorates.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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