Drug interactions
Chlorzoxazone + Difenoxin
Severity: Moderate
Chlorzoxazone and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal related to diphenoxylate, and at higher doses it can cause CNS depression. With chlorzoxazone it may increase drowsiness and, rarely, respiratory depression.
What this interaction means in plain words
Chlorzoxazone and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid activity and central muscle relaxation.
What to do
Use the recommended difenoxin dose and monitor for excess sedation. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Difenoxin
Frequently asked questions
Can I take Chlorzoxazone with Difenoxin?
MediHelp rates the interaction as moderate. Chlorzoxazone and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal related to diphenoxylate, and at higher doses it can cause CNS depression. With chlorzoxazone it may increase drowsiness and, rarely, respiratory depression.
How serious is the interaction between Chlorzoxazone and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the recommended difenoxin dose and monitor for excess sedation. Advise against driving until the response is known.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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