Drug interactions
Chlorzoxazone + Droperidol
Severity: Moderate
Chlorzoxazone and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol has marked sedative effects and chlorzoxazone adds to central depression. Together they can cause excessive sedation and hypotension, and droperidol also carries a separate QT prolongation risk.
What this interaction means in plain words
Chlorzoxazone and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism and sedation by droperidol plus the central muscle relaxant action of chlorzoxazone.
What to do
Monitor sedation level and vital signs after droperidol administration. Reduce the doses of the sedating drugs if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Droperidol?
MediHelp rates the interaction as moderate. Chlorzoxazone and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol has marked sedative effects and chlorzoxazone adds to central depression. Together they can cause excessive sedation and hypotension, and droperidol also carries a separate QT prolongation risk.
How serious is the interaction between Chlorzoxazone and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and vital signs after droperidol administration. Reduce the doses of the sedating drugs if oversedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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