Drug interactions
Chlorzoxazone + Esketamine
Severity: Moderate
Chlorzoxazone and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness and dizziness. Combined with esketamine, sedation and impaired coordination may be intensified.
What this interaction means in plain words
Chlorzoxazone and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation during the post-dose observation period. Avoid driving and hazardous activities after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Esketamine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness and dizziness. Combined with esketamine, sedation and impaired coordination may be intensified.
How serious is the interaction between Chlorzoxazone and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during the post-dose observation period. Avoid driving and hazardous activities after treatment.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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