Drug interactions
Chlorzoxazone + Ethanol
Severity: Moderate
Chlorzoxazone and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol and chlorzoxazone both depress the central nervous system. Drinking while taking chlorzoxazone increases drowsiness, dizziness and impaired judgment and coordination.
What this interaction means in plain words
Chlorzoxazone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with alcohol enhancing GABA-A activity and chlorzoxazone acting as a central muscle relaxant.
What to do
Advise patients to avoid alcohol while taking chlorzoxazone. Counsel against driving or operating machinery if alcohol has been consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Ethanol?
MediHelp rates the interaction as moderate. Chlorzoxazone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol and chlorzoxazone both depress the central nervous system. Drinking while taking chlorzoxazone increases drowsiness, dizziness and impaired judgment and coordination.
How serious is the interaction between Chlorzoxazone and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while taking chlorzoxazone. Counsel against driving or operating machinery if alcohol has been consumed.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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