Drug interactions
Chlorzoxazone + Flurazepam
Severity: Moderate
Chlorzoxazone and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting hypnotic benzodiazepine, and chlorzoxazone is also sedating. The combination can cause pronounced and prolonged drowsiness, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Chlorzoxazone and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and central muscle relaxation.
What to do
Use the lowest effective doses and monitor for oversedation, especially in older adults because of flurazepam's long-acting metabolite. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Flurazepam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting hypnotic benzodiazepine, and chlorzoxazone is also sedating. The combination can cause pronounced and prolonged drowsiness, psychomotor impairment and respiratory depression.
How serious is the interaction between Chlorzoxazone and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, especially in older adults because of flurazepam's long-acting metabolite. Advise against driving and alcohol.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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