Drug interactions
Chlorzoxazone + Lofepramine
Severity: Moderate
Chlorzoxazone and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative properties, and chlorzoxazone also causes drowsiness. Together they may increase sedation and impair psychomotor performance.
What this interaction means in plain words
Chlorzoxazone and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Warn patients about drowsiness and avoid driving until the response is known. Reduce the dose of one drug if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Lofepramine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative properties, and chlorzoxazone also causes drowsiness. Together they may increase sedation and impair psychomotor performance.
How serious is the interaction between Chlorzoxazone and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving until the response is known. Reduce the dose of one drug if sedation is troublesome.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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