Drug interactions
Chlorzoxazone + Loprazolam
Severity: Moderate
Chlorzoxazone and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and centrally acting muscle relaxants both depress the central nervous system. Used together they can cause marked drowsiness, impaired coordination, falls and, at higher doses, respiratory depression.
What this interaction means in plain words
Chlorzoxazone and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and warn about driving and alcohol. Monitor older or frail patients closely for sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Loprazolam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and centrally acting muscle relaxants both depress the central nervous system. Used together they can cause marked drowsiness, impaired coordination, falls and, at higher doses, respiratory depression.
How serious is the interaction between Chlorzoxazone and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about driving and alcohol. Monitor older or frail patients closely for sedation and falls.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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