Drug interactions
Chlorzoxazone + Moxonidine
Severity: Moderate
Chlorzoxazone and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine, a centrally acting antihypertensive, can cause drowsiness and dizziness, and chlorzoxazone has similar effects. Together they may increase sedation and orthostatic symptoms.
What this interaction means in plain words
Chlorzoxazone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and blood-pressure lowering.
What to do
Monitor for drowsiness and orthostatic hypotension, particularly when starting or increasing doses. Advise caution when driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Moxonidine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine, a centrally acting antihypertensive, can cause drowsiness and dizziness, and chlorzoxazone has similar effects. Together they may increase sedation and orthostatic symptoms.
How serious is the interaction between Chlorzoxazone and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and orthostatic hypotension, particularly when starting or increasing doses. Advise caution when driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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