Drug interactions
Chlorzoxazone + Olopatadine intranasal
Severity: Moderate
Chlorzoxazone and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olopatadine nasal spray can cause somnolence, and combining it with a sedating muscle relaxant increases CNS depression. This may worsen daytime psychomotor impairment.
What this interaction means in plain words
Chlorzoxazone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from pharmacodynamic synergism.
What to do
Counsel patients to avoid driving and hazardous tasks, and consider a non-sedating alternative to the nasal antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Chlorzoxazone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olopatadine nasal spray can cause somnolence, and combining it with a sedating muscle relaxant increases CNS depression. This may worsen daytime psychomotor impairment.
How serious is the interaction between Chlorzoxazone and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous tasks, and consider a non-sedating alternative to the nasal antihistamine.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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