Drug interactions
Chlorzoxazone + Orphenadrine
Severity: Moderate
Chlorzoxazone and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are muscle relaxants with sedative effects, and orphenadrine also has anticholinergic activity. Using both is duplicative and may cause excess drowsiness, confusion and dizziness.
What this interaction means in plain words
Chlorzoxazone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression, with added anticholinergic effects from orphenadrine.
What to do
Avoid using two muscle relaxants together when possible. If both are used, monitor older patients for confusion and oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Orphenadrine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are muscle relaxants with sedative effects, and orphenadrine also has anticholinergic activity. Using both is duplicative and may cause excess drowsiness, confusion and dizziness.
How serious is the interaction between Chlorzoxazone and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants together when possible. If both are used, monitor older patients for confusion and oversedation.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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