Drug interactions
Chlorzoxazone + Pholcodine
Severity: Moderate
Chlorzoxazone and Pholcodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive with sedative potential, and chlorzoxazone adds drowsiness. The combination may increase sedation and impair alertness.
What this interaction means in plain words
Chlorzoxazone and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Counsel patients on drowsiness and avoiding driving. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Pholcodine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pholcodine is an opioid antitussive with sedative potential, and chlorzoxazone adds drowsiness. The combination may increase sedation and impair alertness.
How serious is the interaction between Chlorzoxazone and Pholcodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on drowsiness and avoiding driving. Use the lowest effective doses.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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