Drug interactions
Chlorzoxazone + Pimozide
Severity: Moderate
Chlorzoxazone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone may add to sedation and motor impairment from pimozide. The more significant issue with pimozide is QT prolongation, which chlorzoxazone does not clearly affect, so the interaction is mainly additive drowsiness.
What this interaction means in plain words
Chlorzoxazone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and dizziness, and counsel on driving. Continue standard ECG and electrolyte monitoring for pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Pimozide?
MediHelp rates the interaction as moderate. Chlorzoxazone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone may add to sedation and motor impairment from pimozide. The more significant issue with pimozide is QT prolongation, which chlorzoxazone does not clearly affect, so the interaction is mainly additive drowsiness.
How serious is the interaction between Chlorzoxazone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, and counsel on driving. Continue standard ECG and electrolyte monitoring for pimozide.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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