Drug interactions
Chlorzoxazone + Protriptyline
Severity: Moderate
Chlorzoxazone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and psychomotor impairment, so taking them together may deepen sedation and impair driving or other tasks requiring alertness. Protriptyline is less sedating than other tricyclics, but the effect can still be additive.
What this interaction means in plain words
Chlorzoxazone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Counsel the patient about drowsiness and avoiding driving until the response is known. Reduce the dose of either drug if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Protriptyline?
MediHelp rates the interaction as moderate. Chlorzoxazone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and psychomotor impairment, so taking them together may deepen sedation and impair driving or other tasks requiring alertness. Protriptyline is less sedating than other tricyclics, but the effect can still be additive.
How serious is the interaction between Chlorzoxazone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and avoiding driving until the response is known. Reduce the dose of either drug if excessive sedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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