Drug interactions

Chlorzoxazone + Remimazolam

Severity: Major

Chlorzoxazone and Remimazolam: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Remimazolam is a benzodiazepine sedative, and chlorzoxazone adds CNS depression. Together they may cause deeper sedation and respiratory depression than expected.

What this interaction means in plain words

Chlorzoxazone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chlorzoxazone belongs to Musculoskeletal; Remimazolam belongs to Central Nervous System.

Evidence level: Moderate

Why it happens

Additive CNS depression through GABA-A potentiation by remimazolam and sedative effects of chlorzoxazone.

What to do

Titrate remimazolam carefully and continuously monitor oxygen saturation, respiration and vital signs during and after the procedure. Ensure resuscitation equipment and trained personnel are available.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

BYFAVO - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: CNS depressant medications; "The sedative effect of intravenous BYFAVO can be accentuated by concomitantly administered CNS depressant medications, including opioid analgesics, other benzod") — DailyMed (FDA label)

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Frequently asked questions

Can I take Chlorzoxazone with Remimazolam?

MediHelp rates the interaction as major. Chlorzoxazone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is a benzodiazepine sedative, and chlorzoxazone adds CNS depression. Together they may cause deeper sedation and respiratory depression than expected.

How serious is the interaction between Chlorzoxazone and Remimazolam?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and continuously monitor oxygen saturation, respiration and vital signs during and after the procedure. Ensure resuscitation equipment and trained personnel are available.

What other medicines interact with Chlorzoxazone?

MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.

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