Drug interactions
Chlorzoxazone + Thiothixene
Severity: Moderate
Chlorzoxazone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic that causes sedation, and together with chlorzoxazone may increase drowsiness and psychomotor impairment. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Chlorzoxazone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antihistaminic or alpha-adrenergic effects.
What to do
Monitor for oversedation and dizziness, particularly at initiation or dose increase. Reduce the dose of one agent if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Thiothixene?
MediHelp rates the interaction as moderate. Chlorzoxazone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic that causes sedation, and together with chlorzoxazone may increase drowsiness and psychomotor impairment. Orthostatic hypotension may also be additive.
How serious is the interaction between Chlorzoxazone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and dizziness, particularly at initiation or dose increase. Reduce the dose of one agent if impairment occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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