Drug interactions
Chlorzoxazone + Topiramate
Severity: Moderate
Chlorzoxazone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone causes drowsiness and dizziness, and topiramate also causes sedation and cognitive slowing. Used together, they can add to CNS depression and impair alertness. Topiramate may modestly alter chlorzoxazone handling but sedation is the main concern.
What this interaction means in plain words
Chlorzoxazone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel on driving and alcohol avoidance and monitor for excessive sedation. Reduce the chlorzoxazone dose if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Topiramate
Frequently asked questions
Can I take Chlorzoxazone with Topiramate?
MediHelp rates the interaction as moderate. Chlorzoxazone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone causes drowsiness and dizziness, and topiramate also causes sedation and cognitive slowing. Used together, they can add to CNS depression and impair alertness. Topiramate may modestly alter chlorzoxazone handling but sedation is the main concern.
How serious is the interaction between Chlorzoxazone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on driving and alcohol avoidance and monitor for excessive sedation. Reduce the chlorzoxazone dose if drowsiness is troublesome.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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