Drug interactions
Chlorzoxazone + Triazolam
Severity: Moderate
Chlorzoxazone and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, and their combination can increase sedation, dizziness, memory impairment and fall risk. The effect may impair next-day function.
What this interaction means in plain words
Chlorzoxazone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABAergic and central muscle relaxant effects.
What to do
Use the lowest effective doses and avoid alcohol. Counsel patients against driving or hazardous activity after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Triazolam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, and their combination can increase sedation, dizziness, memory impairment and fall risk. The effect may impair next-day function.
How serious is the interaction between Chlorzoxazone and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid alcohol. Counsel patients against driving or hazardous activity after dosing.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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