Drug interactions
Cholera vaccine + Decitabine
Severity: Moderate
Cholera vaccine and Decitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Decitabine causes myelosuppression and immune impairment, which can reduce the antibody response to the cholera vaccine. Protection may be lower than expected.
What this interaction means in plain words
Cholera vaccine and Decitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Where possible, vaccinate at least 2 weeks before starting therapy or defer until immune recovery. Consider revaccination after therapy if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Decitabine
Frequently asked questions
Can I take Cholera vaccine with Decitabine?
MediHelp rates the interaction as moderate. Cholera vaccine and Decitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Decitabine causes myelosuppression and immune impairment, which can reduce the antibody response to the cholera vaccine. Protection may be lower than expected.
How serious is the interaction between Cholera vaccine and Decitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least 2 weeks before starting therapy or defer until immune recovery. Consider revaccination after therapy if given during treatment.
What other medicines interact with Decitabine?
MediHelp also lists interactions of Decitabine with, for example, Dengue vaccine, Etrasimod, Fingolimod. The full list is on the Decitabine page.
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