Drug interactions
Cholera vaccine + Guselkumab
Severity: Moderate
Cholera vaccine and Guselkumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral cholera vaccine is live attenuated in some products, while others are inactivated. Guselkumab might reduce the vaccine response, and live products carry a theoretical infection risk.
What this interaction means in plain words
Cholera vaccine and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-23 inhibition may modulate vaccine immune response; theoretical.
What to do
Complete cholera vaccination before starting guselkumab when travel is planned. If vaccination is needed during therapy, confirm the product type and prefer an inactivated one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Cholera vaccine with Guselkumab?
MediHelp rates the interaction as moderate. Cholera vaccine and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral cholera vaccine is live attenuated in some products, while others are inactivated. Guselkumab might reduce the vaccine response, and live products carry a theoretical infection risk.
How serious is the interaction between Cholera vaccine and Guselkumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete cholera vaccination before starting guselkumab when travel is planned. If vaccination is needed during therapy, confirm the product type and prefer an inactivated one.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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