Drug interactions
Cholera vaccine + Lenalidomide
Severity: Moderate
Cholera vaccine and Lenalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenalidomide is immunomodulatory and often given with other immunosuppressive therapy, which may weaken the antibody response to vaccination. The oral cholera vaccine is a live attenuated product in some formulations, adding theoretical infection risk.
What this interaction means in plain words
Cholera vaccine and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression and impaired immune function from lenalidomide reduce vaccine immunogenicity.
What to do
Where feasible, vaccinate before starting lenalidomide and avoid live vaccines during treatment. Consider confirming immunity if the patient travels to high-risk areas.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
- Etrasimod + Lenalidomide Moderate
Frequently asked questions
Can I take Cholera vaccine with Lenalidomide?
MediHelp rates the interaction as moderate. Cholera vaccine and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenalidomide is immunomodulatory and often given with other immunosuppressive therapy, which may weaken the antibody response to vaccination. The oral cholera vaccine is a live attenuated product in some formulations, adding theoretical infection risk.
How serious is the interaction between Cholera vaccine and Lenalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate before starting lenalidomide and avoid live vaccines during treatment. Consider confirming immunity if the patient travels to high-risk areas.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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