Drug interactions
Denosumab + Lenalidomide
Severity: Moderate
Denosumab and Lenalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenalidomide commonly causes neutropenia and immune compromise, and denosumab labeling warns of serious infections. Combined use, often in myeloma, may increase infection risk.
What this interaction means in plain words
Denosumab and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Lenalidomide belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: immunomodulatory myelosuppression combined with RANKL inhibition.
What to do
Monitor blood counts and watch for infection, considering antimicrobial prophylaxis per local myeloma practice. Treat febrile episodes promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Denosumab and Lenalidomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Etrasimod + Lenalidomide Moderate
Frequently asked questions
Can I take Denosumab with Lenalidomide?
MediHelp rates the interaction as moderate. Denosumab and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenalidomide commonly causes neutropenia and immune compromise, and denosumab labeling warns of serious infections. Combined use, often in myeloma, may increase infection risk.
How serious is the interaction between Denosumab and Lenalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection, considering antimicrobial prophylaxis per local myeloma practice. Treat febrile episodes promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
