Drug interactions
Etrasimod + Lenalidomide
Severity: Moderate
Etrasimod and Lenalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes and has not been studied with antineoplastic or immunomodulating agents. Combined with lenalidomide, which causes myelosuppression and immune effects, additive risk of infection and cytopenias is possible.
What this interaction means in plain words
Etrasimod and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Lenalidomide belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation, which sequesters lymphocytes, and lenalidomide immunomodulation and myelosuppression.
What to do
Avoid combining where feasible; if needed, monitor blood counts and signs of infection closely during and for weeks after etrasimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Lenalidomide?
MediHelp rates the interaction as moderate. Etrasimod and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod reduces circulating lymphocytes and has not been studied with antineoplastic or immunomodulating agents. Combined with lenalidomide, which causes myelosuppression and immune effects, additive risk of infection and cytopenias is possible.
How serious is the interaction between Etrasimod and Lenalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where feasible; if needed, monitor blood counts and signs of infection closely during and for weeks after etrasimod.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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