Drug interactions
Cholera vaccine + Neomycin
Severity: Moderate
Cholera vaccine and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin has activity against gut flora and may reduce the viability of the live attenuated oral cholera vaccine strain. This could lead to a weaker immune response.
What this interaction means in plain words
Cholera vaccine and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
What to do
Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Cholera vaccine with Neomycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin has activity against gut flora and may reduce the viability of the live attenuated oral cholera vaccine strain. This could lead to a weaker immune response.
How serious is the interaction between Cholera vaccine and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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