Drug interactions
Cholera vaccine + Obinutuzumab
Severity: Moderate
Cholera vaccine and Obinutuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab depletes B cells and markedly blunts antibody responses to vaccines. Cholera vaccine may therefore provide inadequate protection. Live attenuated cholera vaccine carries an added theoretical infection risk in immunocompromised patients.
What this interaction means in plain words
Cholera vaccine and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
B-cell depletion by obinutuzumab impairs humoral vaccine response.
What to do
Where possible give the vaccine at least several weeks before starting obinutuzumab, and avoid live vaccines during and after therapy until B-cell recovery. Do not rely on the vaccine for protection in travellers to endemic areas.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Cholera vaccine with Obinutuzumab?
MediHelp rates the interaction as moderate. Cholera vaccine and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obinutuzumab depletes B cells and markedly blunts antibody responses to vaccines. Cholera vaccine may therefore provide inadequate protection. Live attenuated cholera vaccine carries an added theoretical infection risk in immunocompromised patients.
How serious is the interaction between Cholera vaccine and Obinutuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible give the vaccine at least several weeks before starting obinutuzumab, and avoid live vaccines during and after therapy until B-cell recovery. Do not rely on the vaccine for protection in travellers to endemic areas.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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