Drug interactions
Cholera vaccine + Pemetrexed
Severity: Moderate
Cholera vaccine and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemetrexed is a cytotoxic antimetabolite that suppresses immune function and may blunt the antibody response to the cholera vaccine, leaving the patient inadequately protected. The vaccine in use is typically a live attenuated oral product, which also raises a theoretical concern in immunosuppressed patients.
What this interaction means in plain words
Cholera vaccine and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppressive and immunosuppressive effects of pemetrexed reduce vaccine immune response.
What to do
Where possible, give the vaccine at least 2 weeks before starting chemotherapy or defer until immune recovery after treatment. If vaccinated during therapy, consider the response may be inadequate and maintain other protective measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Cholera vaccine with Pemetrexed?
MediHelp rates the interaction as moderate. Cholera vaccine and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemetrexed is a cytotoxic antimetabolite that suppresses immune function and may blunt the antibody response to the cholera vaccine, leaving the patient inadequately protected. The vaccine in use is typically a live attenuated oral product, which also raises a theoretical concern in immunosuppressed patients.
How serious is the interaction between Cholera vaccine and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine at least 2 weeks before starting chemotherapy or defer until immune recovery after treatment. If vaccinated during therapy, consider the response may be inadequate and maintain other protective measures.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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