Drug interactions
Cholera vaccine + Pralatrexate
Severity: Minor
Cholera vaccine and Pralatrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic antimetabolites can suppress humoral immune responses, so the oral cholera vaccine may produce lower protective antibody levels. Patients on pralatrexate may therefore remain susceptible to cholera despite vaccination.
What this interaction means in plain words
Cholera vaccine and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression from pralatrexate reduces the immune response to vaccination.
What to do
Where feasible, give the vaccine before starting chemotherapy or during a treatment-free interval, and do not count on full protection if given during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Cholera vaccine with Pralatrexate?
MediHelp rates the interaction as minor. Cholera vaccine and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cytotoxic antimetabolites can suppress humoral immune responses, so the oral cholera vaccine may produce lower protective antibody levels. Patients on pralatrexate may therefore remain susceptible to cholera despite vaccination.
How serious is the interaction between Cholera vaccine and Pralatrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, give the vaccine before starting chemotherapy or during a treatment-free interval, and do not count on full protection if given during therapy.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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