Drug interactions
Cholera vaccine + Prednisone
Severity: Moderate
Cholera vaccine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at greater than physiologic doses can blunt the immune response to vaccines. The oral cholera vaccine may therefore give reduced protection in a patient on immunosuppressive prednisone doses.
What this interaction means in plain words
Cholera vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced immunosuppression reduces vaccine immunogenicity.
What to do
Where possible, vaccinate before starting immunosuppressive therapy or when the dose is low. Otherwise advise continued food and water precautions, as protection may be incomplete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Cholera vaccine with Prednisone?
MediHelp rates the interaction as moderate. Cholera vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at greater than physiologic doses can blunt the immune response to vaccines. The oral cholera vaccine may therefore give reduced protection in a patient on immunosuppressive prednisone doses.
How serious is the interaction between Cholera vaccine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting immunosuppressive therapy or when the dose is low. Otherwise advise continued food and water precautions, as protection may be incomplete.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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