Drug interactions
Cholestyramine + Cortisone
Severity: Moderate
Cholestyramine and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine may bind oral cortisone in the gut and reduce its absorption. This can lessen glucocorticoid effect, which matters in adrenal insufficiency.
What this interaction means in plain words
Cholestyramine and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Resin binding of cortisone in the gastrointestinal tract reduces absorption.
What to do
Give cortisone at least 1 hour before or 4-6 hours after cholestyramine. Monitor clinical response and adrenal replacement adequacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholestyramine and Cortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Cortisone?
MediHelp rates the interaction as moderate. Cholestyramine and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine may bind oral cortisone in the gut and reduce its absorption. This can lessen glucocorticoid effect, which matters in adrenal insufficiency.
How serious is the interaction between Cholestyramine and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cortisone at least 1 hour before or 4-6 hours after cholestyramine. Monitor clinical response and adrenal replacement adequacy.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
