Drug interactions
Cholestyramine + Dexamethasone-tobramycin
Severity: Moderate
Cholestyramine and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral cholestyramine binds oral corticosteroids in the gut and can reduce their absorption. This matters only when dexamethasone is given orally, as topical or ophthalmic dexamethasone is not affected.
What this interaction means in plain words
Cholestyramine and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Binding of dexamethasone by the bile acid sequestrant in the gastrointestinal tract reduces absorption.
What to do
If dexamethasone is taken orally, give it at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Cholestyramine and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral cholestyramine binds oral corticosteroids in the gut and can reduce their absorption. This matters only when dexamethasone is given orally, as topical or ophthalmic dexamethasone is not affected.
How serious is the interaction between Cholestyramine and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If dexamethasone is taken orally, give it at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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