Drug interactions
Cholestyramine + Doxercalciferol
Severity: Moderate
Cholestyramine and Doxercalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine impairs absorption of fat-soluble vitamins and may reduce absorption of oral doxercalciferol. This could lessen suppression of parathyroid hormone.
What this interaction means in plain words
Cholestyramine and Doxercalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Resin binding and interference with bile-dependent absorption of fat-soluble vitamin D analogs.
What to do
Separate doxercalciferol from cholestyramine by at least 4 hours. Monitor PTH, calcium and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Doxercalciferol?
MediHelp rates the interaction as moderate. Cholestyramine and Doxercalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine impairs absorption of fat-soluble vitamins and may reduce absorption of oral doxercalciferol. This could lessen suppression of parathyroid hormone.
How serious is the interaction between Cholestyramine and Doxercalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doxercalciferol from cholestyramine by at least 4 hours. Monitor PTH, calcium and phosphate.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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