Drug interactions
Cholestyramine + Fenofibrate micronized
Severity: Moderate
Cholestyramine and Fenofibrate micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind fenofibrate and reduce its absorption, weakening its lipid-lowering effect.
What this interaction means in plain words
Cholestyramine and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Resin binding of fenofibrate (fenofibric acid) in the gastrointestinal tract reduces absorption.
What to do
Take fenofibrate at least 1 hour before or 4-6 hours after cholestyramine. Monitor lipid profile.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Fenofibrate micronized?
MediHelp rates the interaction as moderate. Cholestyramine and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can bind fenofibrate and reduce its absorption, weakening its lipid-lowering effect.
How serious is the interaction between Cholestyramine and Fenofibrate micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take fenofibrate at least 1 hour before or 4-6 hours after cholestyramine. Monitor lipid profile.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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