Drug interactions
Cholestyramine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Cholestyramine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, which can weaken diuretic and antihypertensive effects. It may also reduce olmesartan absorption.
What this interaction means in plain words
Cholestyramine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Anion-exchange resin binds the drugs in the gastrointestinal tract, reducing absorption.
What to do
Give the olmesartan-hydrochlorothiazide product at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Cholestyramine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, which can weaken diuretic and antihypertensive effects. It may also reduce olmesartan absorption.
How serious is the interaction between Cholestyramine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the olmesartan-hydrochlorothiazide product at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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