Drug interactions
Cholestyramine + Pitavastatin
Severity: Moderate
Cholestyramine and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine can bind pitavastatin in the gut and reduce its absorption, lowering its effect.
What this interaction means in plain words
Cholestyramine and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.
Why it happens
Bile acid sequestrant binding of pitavastatin in the gastrointestinal tract.
What to do
Give pitavastatin at least 2 hours before or 4 hours after cholestyramine. Monitor lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Pitavastatin?
MediHelp rates the interaction as moderate. Cholestyramine and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine can bind pitavastatin in the gut and reduce its absorption, lowering its effect.
How serious is the interaction between Cholestyramine and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pitavastatin at least 2 hours before or 4 hours after cholestyramine. Monitor lipids.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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