Drug interactions
Cholestyramine + Thyroid desiccated
Severity: Moderate
Cholestyramine and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds thyroid hormones in the gut and reduces absorption of desiccated thyroid, potentially causing hypothyroidism.
What this interaction means in plain words
Cholestyramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Resin binding of thyroid hormones in the gastrointestinal tract reduces absorption.
What to do
Separate thyroid tablets from cholestyramine by at least 4 hours. Monitor TSH and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Thyroid desiccated?
MediHelp rates the interaction as moderate. Cholestyramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds thyroid hormones in the gut and reduces absorption of desiccated thyroid, potentially causing hypothyroidism.
How serious is the interaction between Cholestyramine and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate thyroid tablets from cholestyramine by at least 4 hours. Monitor TSH and adjust the dose if needed.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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