Drug interactions
Cholic acid + Felodipine
Severity: Moderate
Cholic acid and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may inhibit the bile salt export pump, which could cause conjugated bile salts to accumulate in hepatocytes. This may be hepatotoxic in patients taking cholic acid.
What this interaction means in plain words
Cholic acid and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Felodipine belongs to Cardiovascular.
Why it happens
Possible inhibition of the bile salt export pump (BSEP) reduces hepatic bile salt efflux.
What to do
Monitor serum transaminases and bilirubin if the combination is needed, and stop cholic acid if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Felodipine?
MediHelp rates the interaction as moderate. Cholic acid and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine may inhibit the bile salt export pump, which could cause conjugated bile salts to accumulate in hepatocytes. This may be hepatotoxic in patients taking cholic acid.
How serious is the interaction between Cholic acid and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin if the combination is needed, and stop cholic acid if liver injury develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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