Drug interactions
Cholic acid + Glimepiride
Severity: Moderate
Cholic acid and Glimepiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride may inhibit the bile salt export pump, which could reduce clearance of bile acids from hepatocytes. This may worsen accumulation of conjugated bile salts and liver injury in patients receiving cholic acid.
What this interaction means in plain words
Cholic acid and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Glimepiride belongs to Endocrine.
Why it happens
Possible inhibition of BSEP-mediated bile salt efflux by glimepiride.
What to do
Avoid the combination if possible. If both are needed, monitor serum transaminases and bilirubin regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Glimepiride?
MediHelp rates the interaction as moderate. Cholic acid and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride may inhibit the bile salt export pump, which could reduce clearance of bile acids from hepatocytes. This may worsen accumulation of conjugated bile salts and liver injury in patients receiving cholic acid.
How serious is the interaction between Cholic acid and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are needed, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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