Drug interactions
Cholic acid + Hydrochlorothiazide-losartan
Severity: Moderate
Cholic acid and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan may inhibit the bile salt export pump, which could promote accumulation of bile salts in hepatocytes. This is of concern with cholic acid, where liver injury is a recognized risk.
What this interaction means in plain words
Cholic acid and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible inhibition of the bile salt export pump (BSEP) reducing hepatic bile salt efflux.
What to do
Monitor serum transaminases and bilirubin if used together, and stop cholic acid if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Cholic acid and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan may inhibit the bile salt export pump, which could promote accumulation of bile salts in hepatocytes. This is of concern with cholic acid, where liver injury is a recognized risk.
How serious is the interaction between Cholic acid and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin if used together, and stop cholic acid if liver injury develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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