Drug interactions
Choline magnesium trisalicylate + Clopidogrel
Severity: Moderate
Choline magnesium trisalicylate and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates inhibit platelet function and can irritate the gastric mucosa. Taken with clopidogrel, they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Choline magnesium trisalicylate and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects (P2Y12 blockade plus salicylate-mediated COX inhibition) and mucosal injury.
What to do
Avoid the combination unless there is a specific indication. If used, monitor for bleeding and consider gastroprotection with a proton pump inhibitor that has little CYP2C19 inhibition, such as pantoprazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Choline magnesium trisalicylate with Clopidogrel?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates inhibit platelet function and can irritate the gastric mucosa. Taken with clopidogrel, they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Choline magnesium trisalicylate and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless there is a specific indication. If used, monitor for bleeding and consider gastroprotection with a proton pump inhibitor that has little CYP2C19 inhibition, such as pantoprazole.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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