Drug interactions
Choline magnesium trisalicylate + Diflunisal
Severity: Major
Choline magnesium trisalicylate and Diflunisal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two salicylates provides no added benefit and increases the risk of gastrointestinal bleeding, platelet inhibition, renal toxicity and salicylate toxicity. Tinnitus and other signs of salicylism may appear earlier.
What this interaction means in plain words
Choline magnesium trisalicylate and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects: both inhibit cyclooxygenase and platelet function, and both add to the total salicylate load.
What to do
Avoid concurrent use of the two salicylates and choose a single agent. If unavoidable, monitor for bleeding, renal function and signs of salicylism.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Diflunisal?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two salicylates provides no added benefit and increases the risk of gastrointestinal bleeding, platelet inhibition, renal toxicity and salicylate toxicity. Tinnitus and other signs of salicylism may appear earlier.
How serious is the interaction between Choline magnesium trisalicylate and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two salicylates and choose a single agent. If unavoidable, monitor for bleeding, renal function and signs of salicylism.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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