Drug interactions
Choline magnesium trisalicylate + Enalapril-hydrochlorothiazide
Severity: Moderate
Choline magnesium trisalicylate and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so the effect on blood pressure and renal function is probably smaller. Still, high doses may reduce antihypertensive efficacy and affect kidney function when combined with an ACE inhibitor and diuretic.
What this interaction means in plain words
Choline magnesium trisalicylate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated reduction of renal prostaglandin synthesis may reduce renal perfusion and antagonize antihypertensive effects.
What to do
Monitor blood pressure and renal function when starting or changing doses, and keep the patient well hydrated; consider acetaminophen as an alternative for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Enalapril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so the effect on blood pressure and renal function is probably smaller. Still, high doses may reduce antihypertensive efficacy and affect kidney function when combined with an ACE inhibitor and diuretic.
How serious is the interaction between Choline magnesium trisalicylate and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when starting or changing doses, and keep the patient well hydrated; consider acetaminophen as an alternative for analgesia.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
