Drug interactions
Choline magnesium trisalicylate + Fluoxetine
Severity: Moderate
Choline magnesium trisalicylate and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates impair platelet function and irritate the gastrointestinal mucosa, and SSRIs add platelet dysfunction. Together they raise the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Choline magnesium trisalicylate and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function plus salicylate-induced mucosal injury.
What to do
Use the lowest effective salicylate dose and consider a proton pump inhibitor in at-risk patients. Advise reporting melena, hematemesis or unusual bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Fluoxetine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates impair platelet function and irritate the gastrointestinal mucosa, and SSRIs add platelet dysfunction. Together they raise the risk of upper gastrointestinal bleeding.
How serious is the interaction between Choline magnesium trisalicylate and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salicylate dose and consider a proton pump inhibitor in at-risk patients. Advise reporting melena, hematemesis or unusual bruising.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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