Drug interactions
Choline magnesium trisalicylate + Hydrochlorothiazide-losartan
Severity: Moderate
Choline magnesium trisalicylate and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can blunt the blood pressure lowering effect of losartan and hydrochlorothiazide. The combination also raises the risk of reduced kidney function, especially in older or volume-depleted patients, and may contribute to hyperkalemia.
What this interaction means in plain words
Choline magnesium trisalicylate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow, sodium excretion and antihypertensive effect, and impairs glomerular filtration when angiotensin II is also blocked.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate therapy, and keep patients well hydrated. Use the lowest effective salicylate dose or switch to paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can blunt the blood pressure lowering effect of losartan and hydrochlorothiazide. The combination also raises the risk of reduced kidney function, especially in older or volume-depleted patients, and may contribute to hyperkalemia.
How serious is the interaction between Choline magnesium trisalicylate and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing salicylate therapy, and keep patients well hydrated. Use the lowest effective salicylate dose or switch to paracetamol where suitable.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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